Biochemical/Chemical Sensors and Sensor-Array Systems

1. Microfluidic Platform for Pathogen, Toxin, Biomarker, and Chemical Detection with Removable Updatable Sensor Array

NRI’s microfluidic removable updatable sensor array platform technology provides

  • Rich abilities to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens,
  • A unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors–together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework that could be ready standardized,
  • Wide ranges of new inexpensive diverse sensor array strategies that can be configured for dramatic statistical enhancing through novel statistical processing tied with ‘experiment design’ approaches,
  • Deployable, valuable, practical, and previously unavailable solutions for a wide range of field, clinical, and laboratory situations,
  • Deployable, valuable, practical, and previously unavailable solutions addressing many otherwise problematic aspects of field testing for food safety, water safety, epidemic outbreaks, routine diagnosis, and disease monitoring,
  • Many other important fundamental features and capabilities.

NRI is seeking funding to considerably expand the pace, scope, disclosure, and productization of this important work.

See pending US 13/815,757 and other methods and patent assets described in Microfluidic and Lab-On-A-Chip Systems for component, supporting, and associated technologies directly applicable to NRI’s microfluidic removable updatable sensor array platform technology.

2. Miniaturized Optical Absorption Gas Sensor for Microplate Wells, Piping, Conduits, and Enclosed Chambers

NRI’s miniaturized optical absorption gas sensor technology “folds” the optical path by reflecting narrow-beam collimated light paths of specific wavelengths (aligned with gas absorption spectral lines) through a gas mixture within a planar-cross-section or spatial volume to create path lengths far longer than the width of the cross-section. The NRI methodology can be extended to circular and non-circular (elliptical, partially spherical, partially ellipsoidal, or related geometric) cross-section arrangements. Although reflective folded optics have been suggested and applied to various problems, the NRI methodology leverages reflective folded optics in fundamentally different ways. Multiple light wavelengths can be employed sequentially or simultaneously to measure selected spectral absorptions lines spanning near infra-red through visible range to near ultraviolet. Light sources and detectors can be implemented in the form of miniature-sized low-cost semiconductor optoelectronics.

NRI’s miniaturized optical absorption gas sensor technology can be used for per-well gas (for example CO2) monitoring of cell-culture and other types of at least 24-well and 96-well microarray assays (also commonly referred to as “microplates,” “microtiter plates,” and “assays”). Other application areas include piping and conduit arrangements, gas-sample tube systems, laboratory glassware, industrial reaction vessels, gas canisters, gas pressure regulators, gas mixing manifolds, mass flow controllers, CO2 cell incubators, and a wide range of other applications.

Issued Patents

TitlePatent NumberApplication NumberPriority DatesPDFText OnlyRelated Patents

Pending Patents

TitlePublication NumberApplication NumberPriority DatesPDFText OnlyRelated Patents
Microprocessor-Controlled Microfluidic Platform for Pathogen, Toxin, Biomarker, and Chemical Detection with Removable Updatable Sensor Array for Food and Water Safety, Medical, and Laboratory Applications2013/021759813/761,14202/06/2012 02/07/2012 03/22/2012PDFTextBiochemical/Chemical Sensors and Sensor-Array Systems

Pending Unpublished Applications

TitleApplication NumberPriority DatesRelated Patents
Miniaturized Direct Optical Absorption Gas Sensor Arrangements for Enclosed Chambers, Microplate Wells, Piping, and Conduits62/693,618
07/03/2018Biochemical/Chemical Sensors and Sensor-Array Systems