Biochemical Signaling Network Modeling and Instrumentation

For almost two decades, long before current popularity and years before the contemporary Systems Biology community, NRI has self-funded its own R&D into next-generation methods and technologies for:

  • Accurate measurement of rate constants in absolutely essential context of molecular
    crowding,
  • More accurate large-scale nonlinear numerical computational frameworks that do not impose
    inaccuracies of forced linearization, equilibrium, S-models, non-temporal Boolean-logic
    simplifications, etc.
  • Accurate complexity-simplification approximations for high-gain feedback and saturation
    conditions,
  • Modeling the effects of allostery (varying large molecule conformation) on signaling,
  • Merging and splitting of dynamical models,
  • Signaling pathway cross-talk modeling,
  • Powerful rich-feature interactive large-scale model execution environments,
  • SBML exchange of enhanced signaling, metabolic, and genomic models,
  • Additional technologies, proposed protocols, approaches, tools, applications, and
    industrial opportunities that at this writing remain proprietary.

NRI feels its evolving work in this area has become extremely valuable and is seeking funding to considerably expand the pace, scope, disclosure, and productization of this work.

A select few aspects of NRI’s work in these areas are represented in the patent assets listed below.

Issued Patents

TitlePatent NumberApplication NumberPriority DatesPDFText OnlyRelated Patents
Computer System and Microfluidic Instrumentation for Next-Generation Biological Signaling Network Research and Applications9,646,13313/157,30406/09/2010PDFText Biochemical Signaling Network Modeling and Instrumentation
Nonlinear and Lie Algebra Structural Analysis System for Enzyme Cascades, Metabolic Signal Transduction, Signaling Pathways, Catalytic Chemical Reaction Networks, and Immunology8,660,82312/767,794
04/26/2009PDFText Biochemical Signaling Network Modeling and Instrumentation

Pending Patents

TitlePublication NumberApplication NumberPriority DatesPDFText OnlyRelated Patents
Computer system and microfluidic instrumentation for next-generation biological signaling network research and drug discovery2017/023587215/586,16605/03/2017PDFTextBiochemical Signaling Network Modeling and Instrumentation
Modular Biochemical Signaling Laboratory Breadboard for Disease Research, Drug Discovery, Cell Biology, and Other Applications 2014/027304514/216,42003/15/2013PDFTextBiochemical Signaling Network Modeling and Instrumentation
Split, Break, Substitute, and Fragment-Splice Operations for Computer Models of Enzyme Cascades, Metabolic Signal Transduction, Signaling Pathways, Catalytic Chemical Reaction Networks, and Immunology2014/012919614/150,01004/26/2009
PDFText Biochemical Signaling Network Modeling and Instrumentation

Pending Unpublished Applications

TitleApplication NumberPriority DatesRelated Patents
Stepwise and Blockwise Biochemical Network Laboratory Breadboard Systems and Techniques for Signaling, Disease Research, Drug Discovery, Cell Biology, and Other Applications14/485,791
03/15/2013
Biochemical Signaling Network Modeling and Instrumentation
Rate-Constant Invariance Simplifications for Analysis Systems of Biochemical Signaling Networks, Metabolic Networks, Catalytic Chemical Reaction Networks, and Immunology
13/957,370
08/01/2012
Biochemical Signaling Network Modeling and Instrumentation