Next Generation Microplate Technologies

Originating with innovations and insights by Pooncharas Tipgunlankant, NRI has developed an integrated a family of technologies to provide foundations for and facilitate next-generation developments in microplate technologies.

Tipgunlankant’s innovation was driven by impeding problems and unmeetable needs arising in microplate-based human cancer cell-culture NO-donor photosensitizer experiments she designed and performed in study of the “Double-Edge Sword” problem of nitric oxide in human cancer processes and therapies. Her valuable insightful innovations prevent the need for removal of environmentally-sensitive cell culture microplates from closely regulated incubator environments; it initially included per-well active micro-conduit networks for fluid and gas exchanges and dedicated per-well sensors for every well in a microplate. NRI continued to develop her ground-breaking work, and additionally made synergistic adaptations of its Microfluidic and Lab-On-A-Chip Systems and Proximate Microscopic Imaging and Tomography for integrated use in microplate application frameworks. Several major companies have recognized the importance of avoiding removal of environmentally-sensitive cell culture microplates from regulated incubator environments and have adapted their legacy product lines to address some aspects of this. NRI’s technologies, however, go much farther and add tremendous value to common and specialized cell culture experiments. Many features can be integrated into an ANSI-compliant lid for use with a variety of types of commodity microplates.

NRI’s current family of next-generation microplate technologies currently includes:

NRI continues active R&D in each of these areas.

NRI is pleased that startup Advanced Microplate Technologies will be licensing a corresponding collection of NRI technologies and NRI patents applicable to next generation microplates to which they are adding their own original commercialization, integration, and new feature innovations.

Issued Patents

TitlePatent NumberApplication NumberPriority DatesPDFText OnlyRelated Patents
Advanced Microplate, Microtiter, and Microarray Technologies with Per-Well Fluidics, Gas Exchange, Electronic Sensors, and Imaging for Cell-Cultures and Other Applications9,994,88913/844,62108/05/2013PDFText Next-Generation Microplate Technologies

Pending Published Applications

TitlePublication NumberApplication NumberPriority DatesPublish DatePDFText OnlyRelated Patents
Per-Well Imaging Arrangements for Advanced Microplate, Microarray, and Microtiter Technologies2018/029141816/005,38903/15/2013PDFTextNext-Generation Microplate Technologies
Cell Culture Incubator Arrangements for Advanced Microplate, Microarray, and Microtiter Technologies with Per-Well Fluidics, Gas Exchange, Electronic Sensors, and Imaging2018/029141716/005,30803/15/2013PDFTextNext-Generation Microplate Technologies
Per-Well Illumination and Optical Stimulation Arrangements for Advanced Microplate, Microarray, and Microtiter Technologies2018/029141616/005,23203/15/2013PDFText Next-Generation Microplate Technologies
Cap Arrangements Providing Per-Well Fluidics and Gas Exchange for Advanced Microplate, Microarray, and Microtiter Technologies2018/029141516/005,15703/15/2013PDFTextNext-Generation Microplate Technologies
Cap Arrangements with Per-Well Sensors for Advanced Microplate, Microarray, and Microtiter Technologies2018/029141416/004,84403/15/2013PDFTextNext-Generation Microplate Technologies

Pending Unpublished Applications

TitleApplication NumberPriority DatesRelated Patents
Microplate Lid Arrangements for Providing Microplate, Microarray, and Microtiter Technologies with Per-Well Fluidics, Gas Exchange, Electronic Sensors, and Imaging16/502,29607/03/2018Next-Generation Microplate Technologies